dnoise 0.1.0

Denoise Bruker timsTOF .d folders with an iterative vertical ion-mobility feature filter (CLI + library).
Documentation
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title: dnoise
abstract: >-
  Fast, in-place denoising of Bruker timsTOF .d files. Real ions form streaks
  along the ion-mobility axis whereas chemical and electronic noise is short,
  isolated, or scattered; dnoise exploits that structural prior to remove noise
  from MS1 (and optionally MS/MS) frames, writing cleaned .d folders that stay
  drop-in compatible with existing tools. No per-dataset calibration is required.
type: software
authors:
  - given-names: Patrick
    family-names: Garrett
    email: pgarrett@scripps.edu
    orcid: "https://orcid.org/0000-0002-8434-9693"
    affiliation: >-
      Department of Chemical Physiology, The Scripps Research Institute,
      La Jolla, CA, USA
  - given-names: Jolene K.
    family-names: Diedrich
    orcid: "https://orcid.org/0000-0001-6489-4558"
    affiliation: >-
      Multi-Omics Core, The Scripps Research Institute, La Jolla, CA, USA
  - given-names: John R.
    name-suffix: III
    family-names: Yates
    orcid: "https://orcid.org/0000-0001-5267-1672"
    affiliation: >-
      Department of Chemical Physiology, The Scripps Research Institute,
      La Jolla, CA, USA
repository-code: "https://github.com/pgarrett-scripps/dnoise"
url: "https://github.com/pgarrett-scripps/dnoise"
license: MIT
version: 0.1.0
date-released: "2026-08-14"
keywords:
  - mass spectrometry
  - proteomics
  - timsTOF
  - ion mobility
  - denoising
  - PASEF
  - Bruker