tf-binding-rs

A Rust library for predicting transcription factor (TF) binding site occupancy in DNA sequences. This toolkit provides efficient implementations for:

• FASTA file manipulation and sequence processing
• Position Weight Matrix (PWM) handling and Energy Weight Matrix (EWM) conversion
• TF binding site occupancy prediction using biophysical models
• Information content and binding site diversity calculations

Built with performance in mind, this library offers a fast and memory-efficient alternative to traditional Python implementations for genomic analysis.

Features

• 🧬 Fast FASTA file reading and writing
• 📊 PWM/EWM-based binding site scoring
• 🔍 Efficient sequence scanning for binding sites
• 📈 Occupancy landscape calculation
• 🧮 Statistical and thermodynamic calculations

Use Cases

• Genomic sequence analysis
• TF binding site prediction
• Regulatory sequence characterization
• High-throughput DNA sequence processing