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"reason": "Phase 32 Track D screening_500 baseline run: single-target time_ms=2110713.6 (~35min) at depth=5/beam=100/bond-index=off/scorer=on, dominating an entire 100-target shard. Root-node-only (nodes_expanded=1) diagnostic at depth=1/beam=20 showed 19.3s baseline, 15.3s with --bond-index, 5.8s with 0 extracted templates (28 hand-crafted rules only) -- large FIXED per-node cost independent of template count, not primarily template-match-count driven. Root cause not yet isolated (chematic canonicalization/perception cost on this large multi-ring, multi-stereocenter, TIPS-protected macrolide suspected but unconfirmed) -- spun off as a separate hard-tail-latency follow-up, not blocking.",
"added": "2026-07-23"
}
]
}