Pharmsol

Solve pharmacokinetic models using differential equations and their analytical solutions!

Example

ODE based model.

Equation::new_ode(
    |x, p, _t, dx, rateiv, _cov| {
        fetch_cov!(cov, t,);
        fetch_params!(p, ka, ke, _tlag, _v);
        dx[0] = -ka * x[0];
        dx[1] = ka * x[0] - ke * x[1];
    },
    |p| {
        fetch_params!(p, _ka, _ke, tlag, _v);
        lag! {0=>tlag}
    },
    |_p| fa! {},
    |_p, _t, _cov, _x| {},
    |x, p, _t, _cov, y| {
        fetch_params!(p, _ka, _ke, _tlag, v);
        y[0] = x[1] / v;
    },
    (2, 1),
);

Analytic based model.

Equation::new_analytical(
    one_compartment_with_absorption,
    |_p, _cov| {},
    |p| {
        fetch_params!(p, _ka, _ke, tlag, _v);
        lag! {0=>tlag}
    },
    |_p| fa! {},
    |_p, _t, _cov, _x| {},
    |x, p, _t, _cov, y| {
        fetch_params!(p, _ka, _ke, _tlag, v);
        y[0] = x[1] / v;
    },
    (2, 1),
);

Supported analytical models

We are working to support all the standard analytical models.

• One-compartment with IV infusion
• One-compartment with IV infusion and oral absorption
• Two-compartment with IV infusion
• Two-compartment with IV infusion and oral absorption
• Three-compartmental models