libparasail-sys 0.2.1

/**
 * @file
 *
 * @author jeffrey.daily@gmail.com
 *
 * Copyright (c) 2015 Battelle Memorial Institute.
 */
#include "config.h"

#include <stdint.h>
#include <stdlib.h>
#include <string.h>

#include <immintrin.h>

#include "parasail.h"
#include "parasail/memory.h"
#include "parasail/internal_avx.h"


#if HAVE_AVX2_MM256_EXTRACT_EPI32
#define _mm256_extract_epi32_rpl _mm256_extract_epi32
#else
static inline int32_t _mm256_extract_epi32_rpl(__m256i a, int imm) {
    __m256i_32_t A;
    A.m = a;
    return A.v[imm];
}
#endif

#if HAVE_AVX2_MM256_INSERT_EPI32
#define _mm256_insert_epi32_rpl _mm256_insert_epi32
#else
static inline __m256i _mm256_insert_epi32_rpl(__m256i a, int32_t i, int imm) {
    __m256i_32_t A;
    A.m = a;
    A.v[imm] = i;
    return A.m;
}
#endif

#define _mm256_cmplt_epi32_rpl(a,b) _mm256_cmpgt_epi32(b,a)

#define _mm256_slli_si256_rpl(a,imm) _mm256_alignr_epi8(a, _mm256_permute2x128_si256(a, a, _MM_SHUFFLE(0,0,3,0)), 16-imm)

static inline int32_t _mm256_hmax_epi32_rpl(__m256i a) {
    a = _mm256_max_epi32(a, _mm256_permute2x128_si256(a, a, _MM_SHUFFLE(0,0,0,0)));
    a = _mm256_max_epi32(a, _mm256_slli_si256(a, 8));
    a = _mm256_max_epi32(a, _mm256_slli_si256(a, 4));
    return _mm256_extract_epi32_rpl(a, 7);
}


static inline void arr_store(
        __m256i *array,
        __m256i vH,
        int32_t t,
        int32_t seglen,
        int32_t d)
{
    _mm256_store_si256(array + (1LL*d*seglen+t), vH);
}

static inline __m256i arr_load(
        __m256i *array,
        int32_t t,
        int32_t seglen,
        int32_t d)
{
    return _mm256_load_si256(array + (1LL*d*seglen+t));
}

#define FNAME parasail_sw_trace_scan_avx2_256_32
#define PNAME parasail_sw_trace_scan_profile_avx2_256_32

parasail_result_t* FNAME(
        const char * const restrict s1, const int s1Len,
        const char * const restrict s2, const int s2Len,
        const int open, const int gap, const parasail_matrix_t *matrix)
{
    /* declare local variables */
    parasail_profile_t *profile = NULL;
    parasail_result_t *result = NULL;

    /* validate inputs */
    PARASAIL_CHECK_NULL(s2);
    PARASAIL_CHECK_GT0(s2Len);
    PARASAIL_CHECK_GE0(open);
    PARASAIL_CHECK_GE0(gap);
    PARASAIL_CHECK_NULL(matrix);
    if (matrix->type == PARASAIL_MATRIX_TYPE_SQUARE) {
        PARASAIL_CHECK_NULL(s1);
        PARASAIL_CHECK_GT0(s1Len);
    }

    /* initialize local variables */
    profile = parasail_profile_create_avx_256_32(s1, s1Len, matrix);
    if (!profile) return NULL;
    result = PNAME(profile, s2, s2Len, open, gap);

    parasail_profile_free(profile);

    return result;
}

parasail_result_t* PNAME(
        const parasail_profile_t * const restrict profile,
        const char * const restrict s2, const int s2Len,
        const int open, const int gap)
{
    /* declare local variables */
    int32_t i = 0;
    int32_t j = 0;
    int32_t end_query = 0;
    int32_t end_ref = 0;
    int32_t s1Len = 0;
    const parasail_matrix_t *matrix = NULL;
    int32_t segWidth = 0;
    int32_t segLen = 0;
    __m256i* restrict pvP = NULL;
    __m256i* restrict pvE = NULL;
    __m256i* restrict pvHt = NULL;
    __m256i* restrict pvH = NULL;
    __m256i* restrict pvHMax = NULL;
    __m256i* restrict pvGapper = NULL;
    __m256i vGapO;
    __m256i vGapE;
    int32_t NEG_LIMIT = 0;
    int32_t POS_LIMIT = 0;
    __m256i vZero;
    int32_t score = 0;
    __m256i vNegLimit;
    __m256i vPosLimit;
    __m256i vSaturationCheckMin;
    __m256i vSaturationCheckMax;
    __m256i vMaxH;
    __m256i vMaxHUnit;
    __m256i vNegInfFront;
    __m256i vSegLenXgap;
    parasail_result_t *result = NULL;
    __m256i vTZero;
    __m256i vTIns;
    __m256i vTDel;
    __m256i vTDiag;
    __m256i vTDiagE;
    __m256i vTInsE;
    __m256i vTDiagF;
    __m256i vTDelF;

    /* validate inputs */
    PARASAIL_CHECK_NULL(profile);
    PARASAIL_CHECK_NULL(profile->profile32.score);
    PARASAIL_CHECK_NULL(profile->matrix);
    PARASAIL_CHECK_GT0(profile->s1Len);
    PARASAIL_CHECK_NULL(s2);
    PARASAIL_CHECK_GT0(s2Len);
    PARASAIL_CHECK_GE0(open);
    PARASAIL_CHECK_GE0(gap);

    /* initialize stack variables */
    i = 0;
    j = 0;
    end_query = 0;
    end_ref = 0;
    s1Len = profile->s1Len;
    matrix = profile->matrix;
    segWidth = 8; /* number of values in vector unit */
    segLen = (s1Len + segWidth - 1) / segWidth;
    pvP = (__m256i*)profile->profile32.score;
    vGapO = _mm256_set1_epi32(open);
    vGapE = _mm256_set1_epi32(gap);
    NEG_LIMIT = (-open < matrix->min ? INT32_MIN + open : INT32_MIN - matrix->min) + 1;
    POS_LIMIT = INT32_MAX - matrix->max - 1;
    vZero = _mm256_setzero_si256();
    score = NEG_LIMIT;
    vNegLimit = _mm256_set1_epi32(NEG_LIMIT);
    vPosLimit = _mm256_set1_epi32(POS_LIMIT);
    vSaturationCheckMin = vPosLimit;
    vSaturationCheckMax = vNegLimit;
    vMaxH = vNegLimit;
    vMaxHUnit = vNegLimit;
    vNegInfFront = vZero;
    vNegInfFront = _mm256_insert_epi32_rpl(vNegInfFront, NEG_LIMIT, 0);
    vSegLenXgap = _mm256_add_epi32(vNegInfFront,
            _mm256_slli_si256_rpl(_mm256_set1_epi32(-segLen*gap), 4));
    vTZero = _mm256_set1_epi32(PARASAIL_ZERO);
    vTIns  = _mm256_set1_epi32(PARASAIL_INS);
    vTDel  = _mm256_set1_epi32(PARASAIL_DEL);
    vTDiag = _mm256_set1_epi32(PARASAIL_DIAG);
    vTDiagE = _mm256_set1_epi32(PARASAIL_DIAG_E);
    vTInsE = _mm256_set1_epi32(PARASAIL_INS_E);
    vTDiagF = _mm256_set1_epi32(PARASAIL_DIAG_F);
    vTDelF = _mm256_set1_epi32(PARASAIL_DEL_F);


    /* initialize result */
    result = parasail_result_new_trace(segLen, s2Len, 32, sizeof(__m256i));
    if (!result) return NULL;

    /* set known flags */
    result->flag |= PARASAIL_FLAG_SW | PARASAIL_FLAG_SCAN
        | PARASAIL_FLAG_TRACE
        | PARASAIL_FLAG_BITS_32 | PARASAIL_FLAG_LANES_8;

    /* initialize heap variables */
    pvE    = parasail_memalign___m256i(32, segLen);
    pvHt   = parasail_memalign___m256i(32, segLen);
    pvH    = parasail_memalign___m256i(32, segLen);
    pvHMax = parasail_memalign___m256i(32, segLen);
    pvGapper = parasail_memalign___m256i(32, segLen);

    /* validate heap variables */
    if (!pvE) return NULL;
    if (!pvHt) return NULL;
    if (!pvH) return NULL;
    if (!pvHMax) return NULL;
    if (!pvGapper) return NULL;

    parasail_memset___m256i(pvH, vZero, segLen);
    parasail_memset___m256i(pvE, vNegLimit, segLen);
    {
        __m256i vGapper = _mm256_sub_epi32(vZero,vGapO);
        for (i=segLen-1; i>=0; --i) {
            _mm256_store_si256(pvGapper+i, vGapper);
            vGapper = _mm256_sub_epi32(vGapper, vGapE);
        }
    }

    /* outer loop over database sequence */
    for (j=0; j<s2Len; ++j) {
        __m256i vE;
        __m256i vE_ext;
        __m256i vE_opn;
        __m256i vHt;
        __m256i vF;
        __m256i vF_ext;
        __m256i vF_opn;
        __m256i vH;
        __m256i vHp;
        __m256i *pvW;
        __m256i vW;
        __m256i case1;
        __m256i case2;
        __m256i case0;
        __m256i vGapper;
        __m256i vT;
        __m256i vET;
        __m256i vFT;

        /* calculate E */
        /* calculate Ht */
        /* calculate F and H first pass */
        vHp = _mm256_load_si256(pvH+(segLen-1));
        vHp = _mm256_slli_si256_rpl(vHp, 4);
        pvW = pvP + matrix->mapper[(unsigned char)s2[j]]*segLen;
        vHt = vZero;
        vF = vNegLimit;
        for (i=0; i<segLen; ++i) {
            vH = _mm256_load_si256(pvH+i);
            vE = _mm256_load_si256(pvE+i);
            vW = _mm256_load_si256(pvW+i);
            vGapper = _mm256_load_si256(pvGapper+i);
            vE_opn = _mm256_sub_epi32(vH, vGapO);
            vE_ext = _mm256_sub_epi32(vE, vGapE);
            case1 = _mm256_cmpgt_epi32(vE_opn, vE_ext);
            vET = _mm256_blendv_epi8(vTInsE, vTDiagE, case1);
            arr_store(result->trace->trace_table, vET, i, segLen, j);
            vE = _mm256_max_epi32(vE_opn, vE_ext);
            vGapper = _mm256_add_epi32(vHt, vGapper);
            vF = _mm256_max_epi32(vF, vGapper);
            vHp = _mm256_add_epi32(vHp, vW);
            vHt = _mm256_max_epi32(vE, vHp);
            _mm256_store_si256(pvE+i, vE);
            _mm256_store_si256(pvHt+i, vHt);
            _mm256_store_si256(pvH+i, vHp);
            vHp = vH;
        }

        /* pseudo prefix scan on F and H */
        vHt = _mm256_slli_si256_rpl(vHt, 4);
        vGapper = _mm256_load_si256(pvGapper);
        vGapper = _mm256_add_epi32(vHt, vGapper);
        vF = _mm256_max_epi32(vF, vGapper);
        for (i=0; i<segWidth-2; ++i) {
            __m256i vFt = _mm256_slli_si256_rpl(vF, 4);
            vFt = _mm256_add_epi32(vFt, vSegLenXgap);
            vF = _mm256_max_epi32(vF, vFt);
        }

        /* calculate final H */
        vF = _mm256_slli_si256_rpl(vF, 4);
        vF = _mm256_add_epi32(vF, vNegInfFront);
        vH = _mm256_max_epi32(vF, vHt);
        vH = _mm256_max_epi32(vH, vZero);
        for (i=0; i<segLen; ++i) {
            vET = arr_load(result->trace->trace_table, i, segLen, j);
            vHp = _mm256_load_si256(pvH+i);
            vHt = _mm256_load_si256(pvHt+i);
            vF_opn = _mm256_sub_epi32(vH, vGapO);
            vF_ext = _mm256_sub_epi32(vF, vGapE);
            vF = _mm256_max_epi32(vF_opn, vF_ext);
            case1 = _mm256_cmpgt_epi32(vF_opn, vF_ext);
            vFT = _mm256_blendv_epi8(vTDelF, vTDiagF, case1);
            vH = _mm256_max_epi32(vHt, vF);
            vH = _mm256_max_epi32(vH, vZero);
            case0 = _mm256_cmpeq_epi32(vH, vZero);
            case1 = _mm256_cmpeq_epi32(vH, vHp);
            case2 = _mm256_cmpeq_epi32(vH, vF);
            vT = _mm256_blendv_epi8(
                    _mm256_blendv_epi8(vTIns, vTDel, case2),
                    vTDiag, case1);
            vT = _mm256_blendv_epi8(vT, vTZero, case0);
            vT = _mm256_or_si256(vT, vET);
            vT = _mm256_or_si256(vT, vFT);
            arr_store(result->trace->trace_table, vT, i, segLen, j);
            _mm256_store_si256(pvH+i, vH);
            vSaturationCheckMin = _mm256_min_epi32(vSaturationCheckMin, vH);
            vSaturationCheckMax = _mm256_max_epi32(vSaturationCheckMax, vH);
            {
                vMaxH = _mm256_max_epi32(vH, vMaxH);
            }
        } 

        {
            __m256i vCompare = _mm256_cmpgt_epi32(vMaxH, vMaxHUnit);
            if (_mm256_movemask_epi8(vCompare)) {
                score = _mm256_hmax_epi32_rpl(vMaxH);
                vMaxHUnit = _mm256_set1_epi32(score);
                end_ref = j;
                (void)memcpy(pvHMax, pvH, sizeof(__m256i)*segLen);
            }
        }
    }

    /* Trace the alignment ending position on read. */
    {
        int32_t *t = (int32_t*)pvHMax;
        int32_t column_len = segLen * segWidth;
        end_query = s1Len;
        for (i = 0; i<column_len; ++i, ++t) {
            if (*t == score) {
                int32_t temp = i / segWidth + i % segWidth * segLen;
                if (temp < end_query) {
                    end_query = temp;
                }
            }
        }
    }

    if (_mm256_movemask_epi8(_mm256_or_si256(
            _mm256_cmplt_epi32_rpl(vSaturationCheckMin, vNegLimit),
            _mm256_cmpgt_epi32(vSaturationCheckMax, vPosLimit)))) {
        result->flag |= PARASAIL_FLAG_SATURATED;
        score = 0;
        end_query = 0;
        end_ref = 0;
    }

    result->score = score;
    result->end_query = end_query;
    result->end_ref = end_ref;

    parasail_free(pvGapper);
    parasail_free(pvHMax);
    parasail_free(pvH);
    parasail_free(pvHt);
    parasail_free(pvE);

    return result;
}