gtars-overlaprs 0.6.1

Genomic interval overlap operations in Rust
Documentation
//! Core infrastructure for high-performance genomic interval overlap operations in Rust.
//!
//! This crate provides efficient data structures and algorithms for finding overlapping intervals
//! in genomic data. It is part of the [gtars](https://github.com/databio/gtars) project, which
//! provides tools for working with genomic interval data in Rust, Python, and R.
//!
//! ## Features
//!
//! - **Fast overlap queries**: Efficiently find all intervals that overlap with a query interval
//! - **Iterator-based API**: Memory-efficient iteration over overlapping intervals
//! - **Thread-safe**: All data structures implement `Send` and `Sync` for concurrent access
//!
//! All overlap computation logic should live here. Higher-level modules (scoring, tokenizers)
//! wrap this functionality for their specific use cases but should not reimplement overlap
//! algorithms.
//! ## Quick Start
//!
//! ```rust
//! use gtars_overlaprs::{AIList, Overlapper, Interval};
//!
//! // create some genomic intervals (e.g., ChIP-seq peaks)
//! let intervals = vec![
//!     Interval { start: 100u32, end: 200, val: "gene1" },
//!     Interval { start: 150, end: 300, val: "gene2" },
//!     Interval { start: 400, end: 500, val: "gene3" },
//! ];
//!
//! // build the AIList data structure
//! let ailist = AIList::build(intervals);
//!
//! // query for overlapping intervals
//! let overlaps = ailist.find(180, 250);
//! assert_eq!(overlaps.len(), 2); // gene1 and gene2 overlap
//!
//! // or use an iterator for memory-efficient processing
//! for interval in ailist.find_iter(180, 250) {
//!     println!("Found overlap: {:?}", interval);
//! }
//! ```
//!
//! ## Performance
//!
//! The [`AIList`] data structure is optimized for queries on genomic-scale datasets and provides
//! excellent performance for typical genomic interval overlap operations. It uses a decomposition
//! strategy to handle intervals efficiently, particularly when dealing with high-coverage regions
//! common in genomic data.
//!
//! ## IndexedRegionSet
//!
//! For repeated queries against the same reference, use [`IndexedRegionSet`]:
//!
//! ```rust
//! use gtars_overlaprs::IndexedRegionSet;
//! use gtars_core::models::{Region, RegionSet};
//!
//! let reference = RegionSet::from(vec![
//!     Region { chr: "chr1".to_string(), start: 100, end: 200, rest: None },
//!     Region { chr: "chr1".to_string(), start: 300, end: 400, rest: None },
//! ]);
//!
//! let indexed = IndexedRegionSet::new(reference);
//!
//! let query = RegionSet::from(vec![
//!     Region { chr: "chr1".to_string(), start: 150, end: 350, rest: None },
//! ]);
//!
//! // Build once, query many times
//! let counts = indexed.count_overlaps(&query, None);  // Uses pre-built index
//! let any = indexed.any_overlaps(&query, None);       // Reuses same index
//! ```
//!
//! ## Examples
//!
//! ### Finding all genes that overlap a query region
//!
//! ```rust
//! use gtars_overlaprs::{AIList, Overlapper, Interval};
//!
//! let genes = vec![
//!     Interval { start: 1000u32, end: 2000, val: "BRCA1" },
//!     Interval { start: 3000, end: 4000, val: "TP53" },
//!     Interval { start: 5000, end: 6000, val: "EGFR" },
//! ];
//!
//! let gene_index = AIList::build(genes);
//!
//! // query a specific region (e.g., chr17:1500-3500)
//! let overlapping_genes: Vec<&str> = gene_index
//!     .find_iter(1500, 3500)
//!     .map(|interval| interval.val)
//!     .collect();
//!
//! println!("Genes in region: {:?}", overlapping_genes);
//! ```

/// Augmented Interval List implementation.
///
/// See [`AIList`] for details.
pub mod ailist;

/// Binary Interval Search implementation.
///
/// See [`Bits`] for details.
pub mod bits;

/// Genome-wide interval indexing.
///
/// See the [`genome_index`] module for details.
pub mod multi_chrom_overlapper;

/// Indexed region set for efficient repeated queries.
///
/// See [`IndexedRegionSet`] for details.
mod indexed_region_set;
pub use indexed_region_set::IndexedRegionSet;

/// Core traits for overlap operations.
///
/// See [`Overlapper`] for the main trait.
pub mod traits;

// re-exports
pub use self::ailist::AIList;
pub use self::bits::Bits;
pub use self::traits::{Interval, Overlapper};

/// The type of overlap data structure to use.
///
/// This enum allows you to choose between different overlap query implementations,
/// each with different performance characteristics.
///
/// # Variants
///
/// * `AIList` - Use the Augmented Interval List implementation. Best for genomic data
///   with high-coverage regions (e.g., ChIP-seq peaks, dense annotations).
/// * `Bits` - Use the Binary Interval Search implementation. Best for general-purpose
///   overlap queries and sorted sequential queries.
///
pub enum OverlapperType {
    /// Use the Augmented Interval List implementation.
    AIList,
    /// Use the Binary Interval Search implementation.
    Bits,
}

/// Constants used throughout the crate.
pub mod consts {
    /// The command name for overlap operations.
    pub const OVERLAP_CMD: &str = "overlap";
}