edge-rs 0.3.1

//! Host side of the GPU NEBULA path: staging, launch and read-back.
//!
//! The device fits a batch of *requests*: one penalised fit of one gene at one
//! pair of variance components. A gene can carry several requests in a launch,
//! so a one-component search's polish stencil goes out as one batch.
//!
//! ### Layout
//!
//! Per-gene data is uploaded once and stays resident: the positive counts of
//! every gene concatenated, the start of each subject's run within each gene
//! (so a lane finds its first count by binary search), and the per-subject
//! count totals gene-minor. The shared design, offsets and subject boundaries
//! keep their natural order, as every thread walks them identically.
//!
//! Everything per request is **request-minor**: entry `i` of request `q` lives
//! at `i * n_req + q`, so consecutive threads touch consecutive addresses.
//!
//! ### Precision
//!
//! The device is `f32`. Host-derived values, in particular the gamma prior's
//! `alpha` and `lambda`, are computed in `f64` and cast once, as
//! `alpha = 1 / (e^s - 1)` cancels badly for the small `s` most genes have.

use std::time::{Duration, Instant};

use std::future::Future;
use std::pin::Pin;

use cubecl::bytes::Bytes;
use cubecl::prelude::*;
use cubecl::server::ServerError;
use cubecl_utils_rs::prelude::*;
use rayon::prelude::*;

use crate::errors::EdgeErrors;
use crate::gpu::pml_kernel::{OUT_HEADER, PmlGpuTensors, SUBJECT_SLOTS, launch_opt_pml};

///////////
// Input //
///////////

/// One gene's sparse counts, as the batch builder wants them.
///
/// The slices [`crate::sc::pml::PmlData`] borrows, minus the shared design and
/// offsets, plus the variance components and starting point used by
/// [`opt_pml_batch`].
#[derive(Clone, Copy, Debug)]
pub struct GpuGene<'a> {
    /// The positive counts, in increasing cell order.
    pub counts: &'a [f64],
    /// Cell index of each entry of `counts`.
    pub cell_index: &'a [usize],
    /// Count total per subject, length `k`.
    pub subject_total: &'a [f64],
    /// Starting fixed effects, length `nb`.
    pub beta_init: &'a [f64],
    /// nebula's `sigma[0]`, `log(1 + sigma^2)`.
    pub sigma: f64,
    /// nebula's `sigma[1]`, the cell-level negative binomial size.
    pub gamma: f64,
}

/// One penalised fit to run on the device.
#[derive(Clone, Debug)]
pub struct PmlRequest {
    /// Index of the gene, in upload order.
    pub gene: usize,
    /// nebula's `sigma[0]`, `log(1 + sigma^2)`.
    pub subject: f64,
    /// nebula's `sigma[1]`, the cell-level negative binomial size.
    pub cell: f64,
    /// Starting fixed effects, length `nb`.
    pub beta_init: Vec<f64>,
    /// Starting random effects on the log scale, length `k`, or empty to start
    /// every subject at zero as nebula does.
    pub log_w_init: Vec<f64>,
}

////////////
// Output //
////////////

/// What one request brings back.
#[derive(Clone, Debug)]
pub struct PmlReply {
    /// Penalised log-likelihood at the optimum.
    pub log_likelihood: f64,
    /// At the previous iterate.
    pub log_likelihood_prev: f64,
    /// Log-determinant of the random-effect block.
    pub log_det: f64,
    /// Newton steps taken.
    pub iterations: u32,
    /// Backtracks used in the final step.
    pub backtracks: u32,
    /// Fitted fixed effects, length `nb`; empty unless read back in full.
    pub beta: Vec<f64>,
    /// Fitted random effects on the log scale, length `k`; empty unless read
    /// back in full.
    pub log_w: Vec<f64>,
    /// Schur complement, row-major `nb * nb`; empty unless read back in full.
    ///
    /// At the returned point when [`GpuSolveParams::information`] is set.
    /// Without it this, [`Self::subject_curvature`] and [`Self::cross_block`]
    /// are the last Newton step's, one converged step behind the returned
    /// point.
    pub information: Vec<f64>,
    /// Curvature of each random effect, nebula's `vw`, length `k`; empty unless
    /// read back in full.
    pub subject_curvature: Vec<f64>,
    /// Cross block of the information, nebula's `vwb`, row-major `k * nb`;
    /// empty unless read back in full.
    pub cross_block: Vec<f64>,
}

/// What one launch of one request per gene brings back, laid out gene-major.
#[derive(Clone, Debug)]
pub struct GpuPmlBatch {
    /// Fitted fixed effects, row-major `n_genes * nb`.
    pub beta: Vec<f64>,
    /// Schur complement of the observed information, `n_genes * nb * nb`.
    pub information: Vec<f64>,
    /// Penalised log-likelihood at the optimum, one per gene.
    pub log_likelihood: Vec<f64>,
    /// Log-determinant of the random-effect block, one per gene.
    pub log_det: Vec<f64>,
    /// Newton steps taken, one per gene.
    pub iterations: Vec<u32>,
    /// Backtracks used in the final step, one per gene.
    pub backtracks: Vec<u32>,
    /// Number of design columns, the stride of `beta`.
    pub n_coef: usize,
}

/// Knobs for one launch, shared by every request in it.
#[derive(Clone, Copy, Debug)]
pub struct GpuSolveParams {
    /// nebula's absolute stopping tolerance.
    pub eps: f64,
    /// Resolution floor on the objective, relative to its magnitude.
    /// [`crate::gpu::pml_kernel::F32_NOISE_SCALE`] is the default.
    pub noise_scale: f64,
    /// Newton budget.
    pub max_iter: u32,
    /// Backtracking budget within one step.
    pub max_backtrack: u32,
    /// Whether to read back the fitted point (coefficients and random effects)
    /// and the information as well as the scalars.
    pub full: bool,
    /// Whether the information and the log-determinant are wanted. They cost one
    /// more sweep over the cells; without it [`PmlReply::information`] is the
    /// last Newton step's and [`PmlReply::log_det`] is NaN.
    pub information: bool,
}

/// Wall clock inside [`ResidentBatch::submit`] and [`ResidentBatch::collect`],
/// accumulated over launches.
#[derive(Clone, Copy, Debug, Default)]
pub struct SolveTiming {
    /// Request staging on the host, its upload and the launch.
    pub staging: Duration,
    /// Blocked in [`ResidentBatch::collect`] on the device and the copy back.
    pub blocked: Duration,
    /// The scatter into replies.
    pub scatter: Duration,
}

/// A launch in flight: what [`ResidentBatch::submit`] hands back and
/// [`ResidentBatch::collect`] redeems.
///
/// The read-back is already queued behind the kernel, so the host can finish
/// one batch while the device runs the next.
pub struct PendingSolve<'a> {
    /// The packed output on its way back. The read borrows the client it was
    /// queued on.
    out: Pin<Box<dyn Future<Output = Result<Vec<Bytes>, ServerError>> + Send + 'a>>,
    /// Requests in the launch.
    n_req: usize,
    /// Whether the fitted point is wanted.
    full: bool,
    /// Whether the information and the log-determinant were computed.
    information: bool,
}

//////////////////
// Resident set //
//////////////////

/// A set of genes whose data stays on the device between launches.
///
/// The counts and cell indices are the largest upload (hundreds of megabytes),
/// and stage two fits every gene about forty times with only the variance
/// components changed.
pub struct ResidentBatch {
    /// Shared design, row-major `n_cells * nb`.
    design: GpuTensor<f32>,
    /// Shared log offset per cell.
    log_offset: GpuTensor<f32>,
    /// Shared subject boundaries.
    subject_start: GpuTensor<u32>,
    /// Concatenated positive counts.
    counts: GpuTensor<f32>,
    /// Cell index of each count.
    cells: GpuTensor<u32>,
    /// Start of each subject's run in each gene's counts, `[gene * (k + 1) + s]`.
    subject_ptr: GpuTensor<u32>,
    /// Count total per subject, gene-minor.
    subject_total: GpuTensor<f32>,
    /// Unweighted mean design row per subject, `[s * nb + j]`.
    subject_mean: GpuTensor<f32>,
    /// Per-subject scratch, sized for `capacity` requests.
    subject_scratch: GpuTensor<f32>,
    /// Cross-block scratch, sized for `capacity` requests.
    vwb_scratch: GpuTensor<f32>,
    /// Requests the scratch is currently sized for.
    capacity: usize,
    /// Genes resident.
    n_genes: usize,
    /// Subjects.
    k: usize,
    /// Design columns.
    nb: usize,
    /// Per-phase wall clock, when [`Self::time_solves`] switched it on.
    timing: Option<SolveTiming>,
}

impl ResidentBatch {
    /// Uploads everything that does not change between launches.
    ///
    /// ### Params
    ///
    /// * `design` - Shared design, row-major `n_cells * nb`
    /// * `log_offset` - Shared log offset per cell
    /// * `subject_start` - Shared subject boundaries, length `k + 1`
    /// * `genes` - One entry per gene; only the counts, their cell indices and
    ///   the subject totals are read
    /// * `client` - CubeCL compute client
    ///
    /// ### Returns
    ///
    /// The resident set, or [`EdgeErrors`] if the inputs disagree in shape or a
    /// device limit rejects the allocation.
    pub fn upload(
        design: &[f64],
        log_offset: &[f64],
        subject_start: &[usize],
        genes: &[GpuGene<'_>],
        client: &Client,
    ) -> Result<Self, EdgeErrors> {
        let n_genes = genes.len();
        if n_genes == 0 {
            return Err(EdgeErrors::MustBePositive("n_genes".to_string()));
        }
        let n_cells = log_offset.len();
        if n_cells == 0 {
            return Err(EdgeErrors::MustBePositive("n_cells".to_string()));
        }
        let k = subject_start.len().saturating_sub(1);
        if k == 0 {
            return Err(EdgeErrors::MustBePositive("n_subjects".to_string()));
        }
        if !design.len().is_multiple_of(n_cells) {
            return Err(EdgeErrors::LengthMismatch {
                name: "design",
                expected: n_cells,
                got: design.len(),
            });
        }
        let nb = design.len() / n_cells;
        for gene in genes {
            if gene.counts.len() != gene.cell_index.len() {
                return Err(EdgeErrors::LengthMismatch {
                    name: "counts",
                    expected: gene.cell_index.len(),
                    got: gene.counts.len(),
                });
            }
            if gene.subject_total.len() != k {
                return Err(EdgeErrors::LengthMismatch {
                    name: "subject_total",
                    expected: k,
                    got: gene.subject_total.len(),
                });
            }
        }

        // The f32 narrowing runs over tens of millions of values; sequential it
        // is a third of the staging time.
        let design_f32: Vec<f32> = design.par_iter().map(|&v| v as f32).collect();
        let offset_f32: Vec<f32> = log_offset.par_iter().map(|&v| v as f32).collect();
        let start_u32: Vec<u32> = subject_start.iter().map(|&v| v as u32).collect();

        let mut gene_ptr = Vec::with_capacity(n_genes + 1);
        gene_ptr.push(0u32);
        let mut running = 0usize;
        for gene in genes {
            running += gene.counts.len();
            gene_ptr.push(running as u32);
        }
        let nnz = running;

        let mut counts_f32 = vec![0.0f32; nnz];
        let mut cells_u32 = vec![0u32; nnz];
        {
            // Split into the disjoint per-gene runs `gene_ptr` describes, then
            // fill in parallel.
            let mut count_runs: Vec<&mut [f32]> = Vec::with_capacity(n_genes);
            let mut cell_runs: Vec<&mut [u32]> = Vec::with_capacity(n_genes);
            let mut count_rest = counts_f32.as_mut_slice();
            let mut cell_rest = cells_u32.as_mut_slice();
            for gene in genes {
                let (a, b) = count_rest.split_at_mut(gene.counts.len());
                count_runs.push(a);
                count_rest = b;
                let (c, d) = cell_rest.split_at_mut(gene.cell_index.len());
                cell_runs.push(c);
                cell_rest = d;
            }
            count_runs
                .into_par_iter()
                .zip(cell_runs)
                .zip(genes)
                .for_each(|((count_run, cell_run), gene)| {
                    for (out, &v) in count_run.iter_mut().zip(gene.counts) {
                        *out = v as f32;
                    }
                    for (out, &c) in cell_run.iter_mut().zip(gene.cell_index) {
                        *out = c as u32;
                    }
                });
        }

        // Start of each subject's run within each gene's counts, as an absolute
        // index into the concatenated buffer. Counts and subjects are both in
        // cell order, so one merge per gene does it.
        let mut subject_ptr = vec![0u32; n_genes * (k + 1)];
        for (g, gene) in genes.iter().enumerate() {
            let base = gene_ptr[g] as usize;
            let mut p = 0usize;
            for s in 0..=k {
                while p < gene.cell_index.len() && gene.cell_index[p] < subject_start[s] {
                    p += 1;
                }
                subject_ptr[g * (k + 1) + s] = (base + p) as u32;
            }
        }

        let mut subject_total = vec![0.0f32; k * n_genes];
        for (g, gene) in genes.iter().enumerate() {
            for (s, &t) in gene.subject_total.iter().enumerate() {
                subject_total[s * n_genes + g] = t as f32;
            }
        }

        // Anchor for each subject's curvature moments. A column constant within
        // a subject is anchored on its value, not a mean that may round an ulp
        // away, so its deviation is exactly zero and it adds exact zeros to the
        // moments.
        let mut subject_mean = vec![0.0f32; k * nb];
        for s in 0..k {
            let (lo, hi) = (subject_start[s], subject_start[s + 1]);
            if lo == hi {
                continue;
            }
            for j in 0..nb {
                let head = design[lo * nb + j];
                if (lo..hi).all(|c| design[c * nb + j] == head) {
                    subject_mean[s * nb + j] = head as f32;
                } else {
                    let total: f64 = (lo..hi).map(|c| design[c * nb + j]).sum();
                    subject_mean[s * nb + j] = (total / (hi - lo) as f64) as f32;
                }
            }
        }

        let err = |e: CubeclUtilsErrors| EdgeErrors::Gpu(e.to_string());
        let capacity = n_genes;
        Ok(Self {
            design: GpuTensor::from_slice(&design_f32, vec![n_cells * nb], client).map_err(err)?,
            log_offset: GpuTensor::from_slice(&offset_f32, vec![n_cells], client).map_err(err)?,
            subject_start: GpuTensor::from_slice(&start_u32, vec![k + 1], client).map_err(err)?,
            counts: GpuTensor::from_slice(&counts_f32, vec![nnz.max(1)], client).map_err(err)?,
            cells: GpuTensor::from_slice(&cells_u32, vec![nnz.max(1)], client).map_err(err)?,
            subject_ptr: GpuTensor::from_slice(&subject_ptr, vec![n_genes * (k + 1)], client)
                .map_err(err)?,
            subject_total: GpuTensor::from_slice(&subject_total, vec![k * n_genes], client)
                .map_err(err)?,
            subject_mean: GpuTensor::from_slice(&subject_mean, vec![k * nb], client)
                .map_err(err)?,
            subject_scratch: GpuTensor::empty(vec![SUBJECT_SLOTS as usize * k * capacity], client)
                .map_err(err)?,
            vwb_scratch: GpuTensor::empty(vec![k * nb * capacity], client).map_err(err)?,
            capacity,
            n_genes,
            k,
            nb,
            timing: None,
        })
    }

    /// Switches on per-phase timing of every later launch.
    pub fn time_solves(&mut self) {
        self.timing = Some(SolveTiming::default());
    }

    /// What the timed solves have cost so far.
    ///
    /// ### Returns
    ///
    /// The accumulated phases, or `None` unless [`Self::time_solves`] was called.
    pub fn timing(&self) -> Option<SolveTiming> {
        self.timing
    }

    /// Design width of the resident set.
    ///
    /// ### Returns
    ///
    /// The number of design columns.
    pub fn n_coef(&self) -> usize {
        self.nb
    }

    /// Runs a batch of penalised fits against the resident genes.
    ///
    /// [`Self::submit`] then [`Self::collect`], for a caller with nothing to do
    /// in between.
    ///
    /// ### Params
    ///
    /// * `requests` - The fits to run; any gene may appear more than once
    /// * `params` - Knobs shared by every request
    /// * `client` - CubeCL compute client
    ///
    /// ### Returns
    ///
    /// One reply per request, in request order, or [`EdgeErrors`] if a request
    /// is out of range.
    pub fn solve(
        &mut self,
        requests: &[PmlRequest],
        params: &GpuSolveParams,
        client: &Client,
    ) -> Result<Vec<PmlReply>, EdgeErrors> {
        let pending = self.submit(requests, params, client)?;
        self.collect(pending)
    }

    /// Launches a batch of penalised fits and queues its read-back.
    ///
    /// Uploads only per-request scalars and starting points, and returns once
    /// the work is queued. Launches run in submission order, so several may be
    /// in flight against the one scratch.
    ///
    /// ### Params
    ///
    /// * `requests` - The fits to run; any gene may appear more than once
    /// * `params` - Knobs shared by every request
    /// * `client` - CubeCL compute client
    ///
    /// ### Returns
    ///
    /// The launch in flight, or [`EdgeErrors`] if a request is out of range.
    pub fn submit<'a>(
        &mut self,
        requests: &[PmlRequest],
        params: &GpuSolveParams,
        client: &'a Client,
    ) -> Result<PendingSolve<'a>, EdgeErrors> {
        let n_req = requests.len();
        if n_req == 0 {
            return Ok(PendingSolve {
                out: Box::pin(async { Ok(Vec::new()) }),
                n_req,
                full: params.full,
                information: params.information,
            });
        }
        let (n_genes, k, nb) = (self.n_genes, self.k, self.nb);
        let err = |e: CubeclUtilsErrors| EdgeErrors::Gpu(e.to_string());
        let started = Instant::now();

        let mut request_gene = vec![0u32; n_req];
        let mut request_params = vec![0.0f32; 3 * n_req];
        let mut beta_init = vec![0.0f32; nb * n_req];
        let mut log_w_init = vec![0.0f32; k * n_req];
        for (q, req) in requests.iter().enumerate() {
            if req.gene >= n_genes {
                return Err(EdgeErrors::InvalidArgument(format!(
                    "Request {q} names gene {}, but only {n_genes} are resident.",
                    req.gene
                )));
            }
            if req.beta_init.len() != nb {
                return Err(EdgeErrors::LengthMismatch {
                    name: "beta_init",
                    expected: nb,
                    got: req.beta_init.len(),
                });
            }
            // The gamma prior, resolved in f64 exactly as `opt_pml` does.
            let exps = req.subject.exp();
            if !(exps.is_finite() && exps > 1.0) {
                return Err(EdgeErrors::InvalidArgument(format!(
                    "PmlVariance::subject must be finite and strictly positive; request {q} has {}.",
                    req.subject
                )));
            }
            if !(req.cell.is_finite() && req.cell > 0.0) {
                return Err(EdgeErrors::InvalidDispersion(req.cell));
            }
            request_gene[q] = req.gene as u32;
            request_params[q] = (1.0 / (exps - 1.0)) as f32;
            request_params[n_req + q] = (1.0 / (exps.sqrt() * (exps - 1.0))) as f32;
            request_params[2 * n_req + q] = req.cell as f32;
            if !(req.log_w_init.is_empty() || req.log_w_init.len() == k) {
                return Err(EdgeErrors::LengthMismatch {
                    name: "log_w_init",
                    expected: k,
                    got: req.log_w_init.len(),
                });
            }
            for (j, &b) in req.beta_init.iter().enumerate() {
                beta_init[j * n_req + q] = b as f32;
            }
            for (s, &w) in req.log_w_init.iter().enumerate() {
                log_w_init[s * n_req + q] = w as f32;
            }
        }

        if n_req > self.capacity {
            self.subject_scratch =
                GpuTensor::empty(vec![SUBJECT_SLOTS as usize * k * n_req], client).map_err(err)?;
            self.vwb_scratch = GpuTensor::empty(vec![k * nb * n_req], client).map_err(err)?;
            self.capacity = n_req;
        }

        let header = OUT_HEADER as usize;
        let tensors = PmlGpuTensors::<f32> {
            design: self.design.clone(),
            log_offset: self.log_offset.clone(),
            subject_start: self.subject_start.clone(),
            counts: self.counts.clone(),
            cells: self.cells.clone(),
            subject_ptr: self.subject_ptr.clone(),
            subject_total: self.subject_total.clone(),
            subject_mean: self.subject_mean.clone(),
            request_gene: GpuTensor::from_slice(&request_gene, vec![n_req], client).map_err(err)?,
            request_params: GpuTensor::from_slice(&request_params, vec![3 * n_req], client)
                .map_err(err)?,
            beta_init: GpuTensor::from_slice(&beta_init, vec![nb * n_req], client).map_err(err)?,
            log_w_init: GpuTensor::from_slice(&log_w_init, vec![k * n_req], client).map_err(err)?,
            tolerance: GpuTensor::from_slice(
                &[params.eps as f32, params.noise_scale as f32],
                vec![2],
                client,
            )
            .map_err(err)?,
            subject_scratch: self.subject_scratch.clone(),
            vwb_scratch: self.vwb_scratch.clone(),
            out: GpuTensor::empty(
                vec![(header + nb + nb * nb + 2 * k + k * nb) * n_req],
                client,
            )
            .map_err(err)?,
        };

        launch_opt_pml::<f32>(
            &tensors,
            n_genes,
            n_req,
            k,
            nb,
            params.max_iter,
            params.max_backtrack,
            params.information,
            client,
        )?;
        // The read encodes its copy and submits the queue here, not on await, so
        // the next launch can go in behind it.
        let out = Box::pin(client.read_async(vec![tensors.out.handle().clone()]));
        if let Some(t) = self.timing.as_mut() {
            t.staging += started.elapsed();
        }
        Ok(PendingSolve {
            out,
            n_req,
            full: params.full,
            information: params.information,
        })
    }

    /// Waits for a launch and scatters its output into replies.
    ///
    /// ### Params
    ///
    /// * `pending` - The launch, from [`Self::submit`]
    ///
    /// ### Returns
    ///
    /// One reply per request, in request order.
    pub fn collect(&mut self, pending: PendingSolve<'_>) -> Result<Vec<PmlReply>, EdgeErrors> {
        let (n_req, k, nb) = (pending.n_req, self.k, self.nb);
        let header = OUT_HEADER as usize;
        let started = Instant::now();
        let bytes =
            cubecl::future::block_on(pending.out).map_err(|e| EdgeErrors::Gpu(e.to_string()))?;
        let waited = Instant::now();
        let Some(bytes) = bytes.first() else {
            return Ok(Vec::new());
        };
        let out = f32::from_bytes(bytes);
        let rows = |first: usize, n: usize, q: usize| -> Vec<f64> {
            if pending.full {
                (first..first + n)
                    .map(|r| out[r * n_req + q] as f64)
                    .collect()
            } else {
                Vec::new()
            }
        };
        let replies = (0..n_req)
            .map(|q| PmlReply {
                log_likelihood: out[q] as f64,
                log_likelihood_prev: out[n_req + q] as f64,
                log_det: if pending.information {
                    out[2 * n_req + q] as f64
                } else {
                    f64::NAN
                },
                iterations: out[4 * n_req + q] as u32,
                backtracks: out[5 * n_req + q] as u32,
                beta: rows(header, nb, q),
                information: rows(header + nb, nb * nb, q),
                log_w: rows(header + nb + nb * nb, k, q),
                subject_curvature: rows(header + nb + nb * nb + k, k, q),
                cross_block: rows(header + nb + nb * nb + 2 * k, k * nb, q),
            })
            .collect();
        if let Some(t) = self.timing.as_mut() {
            t.blocked += waited - started;
            t.scatter += waited.elapsed();
        }
        Ok(replies)
    }
}

//////////////////////////
// One request per gene //
//////////////////////////

/// Fits every gene once, at its own variance components, on the device.
///
/// Uploads, solves one request per gene at order one, and reads back in full.
/// The one-shot form of [`ResidentBatch`].
///
/// ### Params
///
/// * `design` - Shared design, row-major `n_cells * nb`
/// * `log_offset` - Shared log offset per cell, length `n_cells`
/// * `subject_start` - Shared subject boundaries, length `k + 1`
/// * `genes` - One entry per gene in the batch
/// * `eps` - nebula's absolute stopping tolerance
/// * `noise_scale` - Resolution floor on the objective, relative to its
///   magnitude. [`crate::gpu::pml_kernel::F32_NOISE_SCALE`] is the default; the
///   right value scales with the cell count
/// * `max_iter` - Newton budget
/// * `max_backtrack` - Backtracking budget within one step
/// * `client` - CubeCL compute client
///
/// ### Returns
///
/// The fits, or [`EdgeErrors`] if the inputs disagree in shape or a device
/// limit rejects the work.
#[allow(clippy::too_many_arguments)]
pub fn opt_pml_batch(
    design: &[f64],
    log_offset: &[f64],
    subject_start: &[usize],
    genes: &[GpuGene<'_>],
    eps: f64,
    noise_scale: f64,
    max_iter: u32,
    max_backtrack: u32,
    client: &Client,
) -> Result<GpuPmlBatch, EdgeErrors> {
    let mut resident = ResidentBatch::upload(design, log_offset, subject_start, genes, client)?;
    solve_per_gene(
        &mut resident,
        genes,
        &GpuSolveParams {
            eps,
            noise_scale,
            max_iter,
            max_backtrack,
            full: true,
            information: true,
        },
        client,
    )
}

/// One order-one request per gene against a resident set, laid out gene-major.
///
/// ### Params
///
/// * `resident` - The resident set, in the same gene order as `genes`
/// * `genes` - One entry per gene; `beta_init`, `sigma` and `gamma` are read
/// * `params` - Knobs shared by every request
/// * `client` - CubeCL compute client
///
/// ### Returns
///
/// The fits, gene-major.
pub fn solve_per_gene(
    resident: &mut ResidentBatch,
    genes: &[GpuGene<'_>],
    params: &GpuSolveParams,
    client: &Client,
) -> Result<GpuPmlBatch, EdgeErrors> {
    let nb = resident.n_coef();
    let requests: Vec<PmlRequest> = genes
        .iter()
        .enumerate()
        .map(|(g, gene)| PmlRequest {
            gene: g,
            subject: gene.sigma,
            cell: gene.gamma,
            beta_init: gene.beta_init.to_vec(),
            log_w_init: Vec::new(),
        })
        .collect();
    let replies = resident.solve(&requests, params, client)?;
    Ok(GpuPmlBatch {
        beta: replies
            .iter()
            .flat_map(|r| r.beta.iter().copied())
            .collect(),
        information: replies
            .iter()
            .flat_map(|r| r.information.iter().copied())
            .collect(),
        log_likelihood: replies.iter().map(|r| r.log_likelihood).collect(),
        log_det: replies.iter().map(|r| r.log_det).collect(),
        iterations: replies.iter().map(|r| r.iterations).collect(),
        backtracks: replies.iter().map(|r| r.backtracks).collect(),
        n_coef: nb,
    })
}