# Catalogue of mutations
Also referred to as a "panel" sometimes. This is the catalogue of mutations that confer
resistance (or susceptibility). Provided via the `-i/--panel` option.
This file is a tab-delimited (TSV) file with four columns
1. The gene name of the mutation
2. The mutation in the form `<ref><pos><alt>`, where `<ref>` is the reference nucleotide
or amino acid, `<pos>` is the 1-based position in the gene/protein, and `<alt>` is
the nucleotide or amino acid the reference is changed to. `<pos>` is with respect to
the type of mutation - i.e. if the mutation is a amino acid change, the `<pos>` must
be position within the protein (codon position). Promoter mutations can be specied
with a negative symbol - e.g. -10 means 10 nucleotide before the first position in
the gene. One-letter codes are to be used for amino acids.
3. The residue type - `DNA` (nucleotide change) or `PROT` (amino acid change).
4. Comma-separated list of the drug(s) the mutation confers resistance to. Use `NONE` if
the mutation is not associated with resistance.
## Example
```
pncA TCG196TAG DNA Pyrazinamide
pncA T142R PROT Pyrazinamide
tlyA S159* PROT Capreomycin
embB M306N PROT Ethambutol
rpoB C1275CCA DNA Rifampicin
gid R137P PROT Streptomycin
gid R118S PROT Streptomycin
tlyA G123GC DNA Capreomycin
pncA G97D PROT Pyrazinamide
fabG1 C-15X DNA Ethionamide,Isoniazid
```