# [ `crispr_screen` ]
[](https://github.com/noamteyssier/crispr_screen/blob/main/LICENSE)
[](https://codecov.io/gh/noamteyssier/crispr_screen)
## Introduction
`crispr_screen` is a free, open-source command-line tool that enables easy and
efficient differential expression analysis for CRISPR screens.
It is a recreation of the `MAGeCK` algorithm, which is a form of the `DESeq`
method specifically applied for CRISPR screens. This tool extends the
`MAGeCK` algorithm with the `MAGeCK-INC` method, but also implements the `αRRA`
algorithm described in the original `MAGeCK` paper.
It is a drop-in replacement of current differential expression analyses that is
faster, more stable, and easier to use.