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pub struct HomopolyPairHMM { /* private fields */ }
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A pair Hidden Markov Model for comparing sequences x and y as described by Durbin, R., Eddy, S., Krogh, A., & Mitchison, G. (1998). Biological Sequence Analysis. Current Topics in Genome Analysis 2008. http://doi.org/10.1017/CBO9780511790492. The default model has been extended to consider homopolymer errors, at the cost of more states and transitions.

Implementations

Create a new instance of a HomopolyPairHMM.

Arguments
  • gap_params - parameters for opening or extending gaps
  • hop_params - parameters for opening or extending hops

Calculate the probability of sequence x being related to y via any alignment.

Arguments
  • emission_params - parameters for emission
  • alignment_mode - parameters for free end/start gaps
  • max_edit_dist - maximum edit distance to consider; if not None, perform banded alignment

Trait Implementations

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