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edgeR exactTest: classic two-group negative-binomial exact test for DE. Method: Robinson & Smyth (2008), Biostatistics 9:321-332 — an overdispersed generalization of Fisher’s exact test, conditioning each gene on its total count. Per gene: logFC from per-group one-group NB fits, logCPM from aveLogCPM, and PValue from the doubletail NB convolution after quantile- adjusting both groups to a common library size.