Module pi3k 

PI3K/Akt/mTOR pathway — growth, survival, and metabolism signaling.

Growth factor → Receptor → PI3K → PIP3 → Akt → mTOR
                             ↑                   ↓
                          PTEN (−)         Protein synthesis, cell growth

PTEN dephosphorylates PIP3, acting as a tumor suppressor. Akt inhibits apoptosis and activates mTOR for growth.

Structs

Pi3kConfig

Kinetic parameters for PI3K/Akt/mTOR.

Pi3kFlux

PI3K pathway flux.

Pi3kState

PI3K/Akt/mTOR pathway activation state (fractions 0.0-1.0).