Module jak_stat 

JAK-STAT pathway — cytokine receptor signaling.

Cytokine → Receptor → JAK phosphorylation → STAT phosphorylation
                                               ↓
                                        STAT dimerization
                                               ↓
                                    Nuclear translocation → gene expression
                                               ↓
                                        SOCS (negative feedback)

SOCS (suppressors of cytokine signaling) provide negative feedback by inhibiting JAK activity and targeting receptors for degradation.

Structs

JakStatConfig

Kinetic parameters for JAK-STAT.

JakStatFlux

JAK-STAT pathway flux.

JakStatState

JAK-STAT pathway activation state (fractions 0.0-1.0).