Function vooma 

pub fn vooma(
    y: &Array2<f64>,
    design: Option<&Array2<f64>>,
    span: Option<f64>,
    legacy_span: bool,
) -> Result<VoomaOutput>

vooma(y, design, span, legacy.span) — the continuous-data analog of voom, with no predictor and no blocking.

• y — n_genes x n_samples log-expression matrix (must be finite; R’s vooma disallows NAs).
• design — optional n_samples x p design; defaults to a grand-mean intercept.
• span — LOWESS span; when None it is chosen adaptively (small.n = 50, power = 1/3, or small.n = 10, power = 1/2 when legacy_span).