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pub mod cli;
pub mod extract;
use rust_htslib::{bam, bam::ext::BamRecordExtensions};
use std::fmt::Display;
pub fn positions_on_complimented_sequence(
record: &bam::Record,
input_positions: &[i64],
) -> Vec<i64> {
let positions: Vec<i64> = if record.is_reverse() {
let seq_len = i64::try_from(record.seq_len()).unwrap();
input_positions.iter().rev().map(|p| seq_len - p).collect()
} else {
input_positions.to_vec()
};
positions
}
pub fn search_sorted<T>(a: &Vec<T>, v: &Vec<T>) -> Vec<usize>
where
T: Ord,
T: Display,
{
let mut indexes = Vec::with_capacity(v.len());
let mut a_idx = 0;
for cur_v in v {
while a_idx < a.len() {
if a_idx == 0 && *cur_v <= a[a_idx] {
indexes.push(0);
break;
} else if a_idx == 0 {
a_idx += 1;
}
if a_idx == a.len() - 1 && *cur_v > a[a_idx] {
indexes.push(a_idx + 1);
break;
}
else if (a[a_idx - 1] < *cur_v) && (*cur_v <= a[a_idx]) {
indexes.push(a_idx);
break;
}
a_idx += 1;
}
}
indexes
}
pub fn liftover_closest(record: &bam::Record, positions: &Vec<i64>) -> Vec<i64> {
let mut ref_positions = vec![];
let (_q_pos, r_pos): (Vec<i64>, Vec<i64>) = record
.aligned_pairs()
.map(|[q_pos, r_pos]| (q_pos, r_pos))
.unzip();
let ref_idxs = search_sorted(&r_pos, positions);
for mut idx in ref_idxs {
if idx == r_pos.len() {
idx -= 1;
}
ref_positions.push(r_pos[idx]);
}
ref_positions
}
pub fn liftover_exact(record: &bam::Record, positions: &Vec<i64>) -> Vec<i64> {
let mut ref_positions = vec![];
let mut cur_pos = 0;
for [q_pos, r_pos] in record.aligned_pairs() {
while cur_pos < positions.len() && positions[cur_pos] <= q_pos {
if positions[cur_pos] == q_pos {
log::trace!("Found position: q_pos:{}, r_pos:{}", q_pos, r_pos);
ref_positions.push(r_pos);
}
cur_pos += 1;
}
if cur_pos == positions.len() {
break;
}
}
ref_positions
}
pub fn get_closest_reference_positions(positions: &[i64], record: &bam::Record) -> Vec<i64> {
let positions = positions_on_complimented_sequence(record, positions);
liftover_closest(record, &positions)
}
pub fn get_closest_reference_range(
starts: &[i64],
lengths: &[i64],
record: &bam::Record,
) -> Vec<(i64, i64)> {
let starts = get_closest_reference_positions(starts, record);
let mol_ends: Vec<i64> = starts
.iter()
.zip(lengths.iter())
.map(|(start, length)| start + length)
.collect();
let ends = get_closest_reference_positions(&mol_ends, record);
starts
.iter()
.zip(ends.iter())
.filter(|(&start, &end)| end - start > 0)
.map(|(&start, &end)| (start, end - start))
.collect()
}