Module pseudobulk

Structs§

collapse_pseudobulk: Collapse single-cell counts into Poisson-Gamma pseudobulk parameters.
collapse_pseudobulk_weighted: Same as collapse_pseudobulk, but row-scales the per-(individual, cell_type) count sums by gene_weights[g] before the Gamma update. This is the NB-Fisher housekeeping adjustment used by pinto (see gene_weighting::compute_nb_fisher_weights); housekeeping genes get attenuated in the posterior mean while informative genes stay at w≈1.