1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
// Copyright 2021, 2022 Jeff Knaggs
// Licensed under the MIT license (http://opensource.org/licenses/MIT)
// This file may not be copied, modified, or distributed
// except according to those terms.

mod iterators;

use crate::codec::{Codec, Complement, ReverseComplement};

use bitvec::prelude::*;

use core::borrow::Borrow;
use core::fmt;
use core::hash::{Hash, Hasher};
use core::marker::PhantomData;
use core::ops::{Deref, Index, Range, RangeFull};
use core::str;
pub use core::str::FromStr;

/// A sequence of bit-packed characters of arbitrary length
///
/// Allocated to the heap
#[derive(Debug, PartialEq, Eq)]
pub struct Seq<A: Codec> {
    _p: PhantomData<A>,
    bv: BitVec,
}

/// A slice of a Seq
#[derive(Debug, Eq)]
#[repr(transparent)]
pub struct SeqSlice<A: Codec> {
    _p: PhantomData<A>,
    bs: BitSlice,
}

impl<A: Codec> From<Seq<A>> for usize {
    fn from(slice: Seq<A>) -> usize {
        assert!(slice.bv.len() <= usize::BITS as usize);
        slice.bv.load::<usize>()
    }
}

impl<A: Codec> From<&SeqSlice<A>> for usize {
    fn from(slice: &SeqSlice<A>) -> usize {
        assert!(slice.bs.len() <= usize::BITS as usize);
        slice.bs.load::<usize>()
    }
}

impl<A: Codec> From<&SeqSlice<A>> for u8 {
    fn from(slice: &SeqSlice<A>) -> u8 {
        slice.bs.load::<u8>()
    }
}

impl<A: Codec + Complement + std::fmt::Debug> ReverseComplement for Seq<A> {
    fn revcomp(self) -> Seq<A> {
        let mut v = vec![];
        println!("{}", self);
        for base in self.rev() {
            println!("{:?}", base.to_char());
            v.push(base.comp());
        }
        println!("out {:?}", v);
        Seq::<A>::from_vec(v)
    }
}

#[derive(Debug, Clone)]
pub struct ParseSeqErr;

impl fmt::Display for ParseSeqErr {
    fn fmt(&self, f: &mut fmt::Formatter) -> fmt::Result {
        write!(f, "could not parse sequence")
    }
}

impl<A: Codec> Seq<A> {
    /// Pack binary representations into a bitvector
    pub fn from_vec(vec: Vec<A>) -> Self {
        let mut bv: BitVec = BitVec::new();
        for b in vec.iter() {
            let byte: u8 = (*b).into();
            bv.extend_from_bitslice(&(byte as u8).view_bits::<Lsb0>()[..A::WIDTH as usize]);
        }
        Seq {
            _p: PhantomData,
            bv,
        }
    }

    pub fn nth(&self, i: usize) -> A {
        A::unsafe_from_bits(self[i].into())
    }

    pub fn len(&self) -> usize {
        self.bv.len() / A::WIDTH as usize
    }

    pub fn is_empty(&self) -> bool {
        self.len() == 0
    }

    pub fn bit_and(self, rhs: Seq<A>) -> Seq<A> {
        Seq::<A> {
            _p: PhantomData,
            bv: BitVec::from_bitslice(&(self.bv & rhs.bv)),
        }
    }

    pub fn bit_or(self, rhs: Seq<A>) -> Seq<A> {
        Seq::<A> {
            _p: PhantomData,
            bv: BitVec::from_bitslice(&(self.bv | rhs.bv)),
        }
    }
}

impl<A: Codec> SeqSlice<A> {
    pub fn nth(&self, i: usize) -> A {
        A::unsafe_from_bits(self[i].into())
    }

    pub fn len(&self) -> usize {
        self.bs.len() / A::WIDTH as usize
    }

    pub fn is_empty(&self) -> bool {
        self.len() == 0
    }

    /*
    pub fn contains(&self, _other: &SeqSlice<A>) -> bool {
        unimplemented!()
    }
    */

    pub fn bit_and(&self, rhs: &SeqSlice<A>) -> Seq<A> {
        let mut bv: BitVec = BitVec::from_bitslice(&self.bs);
        bv &= BitVec::from_bitslice(&rhs.bs);

        Seq::<A> {
            _p: PhantomData,
            bv,
        }
    }

    pub fn bit_or(&self, rhs: &SeqSlice<A>) -> Seq<A> {
        let mut bv: BitVec = BitVec::from_bitslice(&self.bs);
        bv |= BitVec::from_bitslice(&rhs.bs);

        Seq::<A> {
            _p: PhantomData,
            bv,
        }
    }
}

impl<A: Codec> PartialEq for SeqSlice<A> {
    fn eq(&self, other: &Self) -> bool {
        self.bs == other.bs
    }
}

impl<A: Codec> Hash for SeqSlice<A> {
    fn hash<H: Hasher>(&self, state: &mut H) {
        self.bs.hash(state);
        self.len().hash(state);
    }
}
impl<A: Codec> Borrow<SeqSlice<A>> for Seq<A> {
    fn borrow(&self) -> &SeqSlice<A> {
        &self[..]
    }
}

impl<A: Codec> Index<Range<usize>> for Seq<A> {
    type Output = SeqSlice<A>;

    fn index(&self, range: Range<usize>) -> &Self::Output {
        let s = range.start * A::WIDTH as usize;
        let e = range.end * A::WIDTH as usize;
        let bs = &self.bv[s..e] as *const BitSlice as *const SeqSlice<A>;
        unsafe { &*bs }
    }
}

impl<A: Codec> Index<RangeFull> for Seq<A> {
    type Output = SeqSlice<A>;

    fn index(&self, _range: RangeFull) -> &Self::Output {
        let bs = &self.bv[0..self.bv.len() as usize] as *const BitSlice as *const SeqSlice<A>;
        unsafe { &*bs }
    }
}

impl<A: Codec> Index<usize> for Seq<A> {
    type Output = SeqSlice<A>;

    fn index(&self, i: usize) -> &Self::Output {
        &self[i..i + 1]
    }
}

impl<A: Codec> Index<Range<usize>> for SeqSlice<A> {
    type Output = SeqSlice<A>;

    fn index(&self, range: Range<usize>) -> &Self::Output {
        let s = range.start * A::WIDTH as usize;
        let e = range.end * A::WIDTH as usize;
        let bs = &self.bs[s..e] as *const BitSlice as *const SeqSlice<A>;
        unsafe { &*bs }
    }
}

impl<A: Codec> Index<RangeFull> for SeqSlice<A> {
    type Output = SeqSlice<A>;

    fn index(&self, _range: RangeFull) -> &Self::Output {
        let bs = &self.bs[0..self.bs.len() as usize] as *const BitSlice as *const SeqSlice<A>;
        unsafe { &*bs }
    }
}

impl<A: Codec> Index<usize> for SeqSlice<A> {
    type Output = SeqSlice<A>;

    fn index(&self, i: usize) -> &Self::Output {
        //A::unsafe_from_bits(self.bs[s..e].load());
        //&self.bs[s..e].load::<u8>()
        &self[i..i + 1]
    }
}

impl<A: Codec> Deref for Seq<A> {
    type Target = SeqSlice<A>;
    fn deref(&self) -> &Self::Target {
        &self[..]
    }
}

impl<A: Codec> AsRef<SeqSlice<A>> for Seq<A> {
    fn as_ref(&self) -> &SeqSlice<A> {
        &self[..]
    }
}

impl<A: Codec> AsRef<Seq<A>> for Seq<A> {
    fn as_ref(&self) -> &Self {
        unimplemented!()
    }
}

impl<A: Codec> From<&SeqSlice<A>> for Seq<A> {
    fn from(_slice: &SeqSlice<A>) -> Self {
        unimplemented!()
    }
}

impl<A: Codec> fmt::Display for Seq<A> {
    fn fmt(&self, f: &mut fmt::Formatter<'_>) -> fmt::Result {
        let mut s = String::new();
        for c in self.bv.chunks_exact(A::WIDTH.into()) {
            s.push_str(&A::unsafe_from_bits(c.load()).to_char().to_string());
        }
        write!(f, "{}", s,)
    }
}

impl<A: Codec> fmt::Display for SeqSlice<A> {
    fn fmt(&self, f: &mut fmt::Formatter<'_>) -> fmt::Result {
        let mut s = String::new();
        for c in self.bs.chunks_exact(A::WIDTH.into()) {
            s.push_str(&A::unsafe_from_bits(c.load()).to_char().to_string());
        }
        write!(f, "{}", s,)
    }
}

impl<A: Codec> FromStr for Seq<A> {
    type Err = ParseSeqErr;

    fn from_str(s: &str) -> Result<Self, Self::Err> {
        let mut v = Vec::new();
        for i in s.chars() {
            match A::from_char(i) {
                Ok(b) => v.push(b),
                Err(_) => return Err(ParseSeqErr),
            }
        }
        Ok(Seq::<A>::from_vec(v))
    }
}

impl<A: Codec> From<Vec<u8>> for Seq<A> {
    fn from(v: Vec<u8>) -> Self {
        Seq::<A>::from_vec(
            v.iter()
                .map(|c| match A::from_char(*c as char) {
                    Ok(base) => base,
                    _ => panic!(),
                })
                .collect(),
        )
    }
}

#[cfg(test)]
mod tests {
    use crate::codec::dna::*;
    use crate::codec::ReverseComplement;
    use crate::seq::{FromStr, Seq, SeqSlice};

    #[test]
    fn test_revcomp() {
        let s1 = dna!("ATGTGTGCGACTGA");
        let s2 = dna!("TCAGTCGCACACAT");
        assert_eq!(s1, s2.revcomp());
    }

    #[test]
    fn test_revcomp_mismatched_sizes() {
        let s1 = dna!("AAAA");
        let s2 = dna!("TTTTT");
        assert_ne!(s1, s2.revcomp());
    }

    #[test]
    fn test_revcomp_idempotence() {
        let s = dna!("AAACGCTACGTACGCGCCTTCGGGGCATCAGCACCAC");
        let sc = dna!("AAACGCTACGTACGCGCCTTCGGGGCATCAGCACCAC");

        assert_eq!(s.revcomp().revcomp(), sc);
    }

    #[test]
    fn slice_indices() {
        let s1 = dna!("ATGTGTGCGACTGATGATCAAACGTAGCTACG");
        let s2 = dna!("ACGTGTGTGCTAGCTAATCGATCAAAAAG");

        assert_eq!(&s1[0], &s2[0]);
        assert_ne!(&s1[1], &s2[1]);
        assert_eq!(&s1[2..4], &s2[2..4]);
        assert_eq!(&s1[15..21], &s2[19..25]);
        assert_ne!(&s1[2..20], &s2[2..20]);
    }

    #[test]
    fn from_slice() {
        let s1 = dna!("ATGTGTGCGACTGATGATCAAACGTAGCTACG");
        let s: &SeqSlice<Dna> = &s1[15..21];
        assert_eq!(format!("{}", s), "GATCAA");
    }
}