Module hpo::stats

Statistical analyses for HpoTerm annotations and enrichment

This module contains methods to calculate the enrichment of Genes or Diseases within sets of HpoTerms, such as a patient’s clinical information.

It can also be used to identify genes or diseases with a similar phenotype, even comparing genes to identify novel gene-interaction-networks.

At the moment, hpo provides only the hypergeometric enrichment analysis using the survival function.

In addition, it provides methods for hierarchical clustering of HpoSets.

Modules

• cluster
  A Cluster of HpoSet for linkage analysis.
• hypergeom
  Calculate the enrichment of a gene or disease in an HpoSet and the probability of enrichment within the hypergeometric distribution.

Structs

• Enrichment
  The fold enrichment and p-value for an enriched Gene or Disease
• Linkage
  Linkage matrices from HpoSets